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In 2004, Upper Merion's Varsity football team, after years of Suburban One dominance, won the school's first PIAA District One Championship against the Great Valley Patriots led by seniors (RB) Marcus Johnson, (QB) Chuck DiNolfi, (RB,WR) Sean Donovan, and D-1 recruit (OT,DT) Dan Butts all two-way starters. UM dominated as every every aspect of it, both in the trenches and the executing. Perhaps it was over excitement and complacency or just Anthony Parker-Boyd's(APB) single will and urgency with a sprinkle of elusiveness. Overall season cap UM went 11-3. Graduating 28 seniors.
UM's varsity track and field relay team placed 6th in the state of Pennsylvania in the 4x800 meter relay at Shippensburg University. Clocking in at a time of 7:55.30, it broke a 26-year-old school record by less than a second. The winning team consisted of leadoff leg, Mike Brothers, 2nd leg, Jon Gries, 3rd leg, Matthew Cunningham, and anchor, Ronak Patel.
Upper Merion Area High School's varsity track and field relay team was crowned Suburban One-American Champions in the 4x400 meter relay in the 2005 Spring season clocking in at 3.25.82. The winning relay team consisted of leadoff leg, Nicholas Tsipras, 2nd leg, Matthew Cunningham, 3rd leg, Ronak Patel, and anchor, Sean Donovan.
Upper Merion Area High School's varsity baseball team was crowned PIAA District I Champions in their 2008-2009 season.
Upper Merion Area High School's varsity boys lacrosse team was crowned Suburban One-American Champions in their 2010 season.
Upper Merion is one of four remaining high schools in the original Suburban One League.
The varsity girls volleyball team was crowned PIAA District I Champions in the 2010-2011 season. They went on to compete in the PIAA State Championship where they finished as the 2nd best volleyball team in Pennsylvania.
In 1987, the school was the setting for Echoes in the Darkness, a book written by Joseph Wambaugh detailing the murder of a teacher and her two children for insurance money, allegedly by the head of the English department and the former principal. This was later converted into a made-for-TV movie and released with critical acclaim.